Methylation and Mutations (5 Part Series)

Part 1: Understanding Methylation & The Role of Epigenetics

Part 1 of Dr. Amy’s “Methylation and Mutations” seminar series explores genetics, the environment, and infectious disease as contributing factors to multifactorial conditions. Multifactorial conditions such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), and Alzheimer’s Disease (AD) are discussed.

Dr. Amy uses metaphors throughout her presentation to help explain the basics of methylation, how methylation impacts every individual, and the role that methylation plays in multifactorial conditions. This presentation also introduces the idea of how to bypass genetic mutations with optimal supplementation and with a better understanding of methylation.

Part 2: Understanding Methylation & The Role of Epigenetics Cont.

Part 2 of Dr. Amy’s “Methylation and Mutations” seminar series is a direct continuation of Part 1. Epigenetics is explained as well as the difference between epigenetics and DNA based mutations. This presentation explores the importance of epigenetics and builds on the basic concepts of methylation from Part 1. Dr. Amy explains in further detail the impact of genes within the methylation cycle, with specific examples from scientific articles.

Part 3: Understanding Mutations & The Importance of B12

Part 3 of Dr. Amy’s “Methylation and Mutations” seminar series picks up where Part 2 left off. This seminar examines the complexity of the entire methylation pathway, including how multiple mutations may be present at one time. Dr. Amy provides an overview of how multiple mutations impact each other and how to support multiple mutations at one time. The seminar emphasizes the importance of studying an entire pathway (as opposed to one biomarker or a single mutation).

Part 3 also provides a detailed review on the importance B12, where B12 impacts the methylation cycle between MTRR and MTR, and how B12 impacts the “long route” around the methylation cycle. Dr. Amy explains what the difference between the many forms of B12 are, and factors that can impact B12 levels in the body.

Part 4: The Role of MTR, MTRR, MTHFR & CBS

Part 4 of Dr. Amy’s “Methylation and Mutations” seminar series examines MTR, MTRR, MTHFR, and CBS mutations. This presentation explores the impact these specific mutations can have on the methylation cycle and the system, and offers supplementation options to support these mutations.

Dr. Amy also touches on the importance of sulfur, nitrogen, and ammonia, as well as the role that cysteine levels play in regulating taurine and glutathione levels in the body.

Part 4 concludes with an overview the SUOX gene, sulfite, and sulfate, all of which are downstream of CBS in the methylation pathway.

Part 5: The Role of BHMT, SHMT, ACAT, AHCY & MAO A

Part 5 of Dr. Amy’s “Methylation and Mutations” seminar series examines BHMT, SHMT, ACAT, AHCY and MAO A mutations. This presentation explores the impact these specific mutations can have on the methylation cycle and the system, and offers supplementation options to support these mutations.

Earlier in the “Methylation and Mutations” series, Dr. Amy discusses the “shortcut” through the methylation pathway. This seminar now examines the “long route” around the methylation pathway.

Additional topics covered in this presentation include stress, attention, the relationship between norepinephrine and dopamine levels, and how norepinephrine and dopamine levels relate to the BHMT gene.