Genetic Testing vs. Biochemical Testing: A Clear Guide to the Differences

difference between dna testing and biochemical testing
January 20, 2025 286 view(s)
Genetic Testing vs. Biochemical Testing: A Clear Guide to the Differences

What Can Genetic Testing Tell You?

Genetic Testing, also called DNA Testing, gives you information about your genetics. The results of a genetic test report usually include information on particular gene variations and reveals if you have certain genetic mutations, referred to as "single nucleotide polymorphisms" (SNPs), that might elevate your risk of developing various health conditions.

While there are thousands of genes and SNPs that can be examined, The DNA Nutrigenomic Test with Methylation Pathway Analysis (MPA) focuses on 30 SNPs that are part of a nutritional pathway in your body, called the methylation cycle. The results provide a molecular understanding of how foods and nutritional supplements can influence health and wellness driven by your unique genetic makeup. 

The Methylation Pathway Analysis (MPA) helps you take the next steps in understanding your results by providing information about each genetic mutation, and offering information about supplementation and at-home test kits based on your genetics. 
 
Unlike biochemical tests where results may vary depending on your current health status, the results of DNA testing will not change, meaning you only need to run this type of test once.

 

A Note From Dr. Amy

I like to use biochemical testing, in conjunction with DNA testing, to customize supplement suggestions specifically for your unique needs. Follow up biochemical testing can be done routinely to check that your supplementation plan is making an appropriate change to better your health. 

 

 

What Can Biochemical Testing Tell You?  

Biochemical testing measures the amount or activity of a particular enzyme or protein from a sample of urine, stool, or hair. Biochemical tests help to assess progress with methylation, as well as nutrient absorption and neurotransmitter levels. 
 
This form of testing is an ongoing tool that can be used to monitor progress and determine what to do next. Unlike genetic results, biochemical test results will change over time. 
 
Each person is unique, so even if two individuals have identical DNA results, their biochemical test results will likely differ greatly depending on their lifestyle choices and experiences. For this reason, many individuals find it beneficial to look at both a DNA profile and data from biochemical tests to further personalize a supplement plan that works for them.

 

A Note From Dr. Amy

While your DNA and SNPs do not change over time, your biochemical test results DO change. Biochemical tests reflect your progress in overcoming imbalances through the use of supplementation. by our environment, diet, toxic burden, and supplementation. 


 

Want to learn even more about the how The Yasko Protocol implements genetic and biochemical testing? Check out Dr. Amy’s free Getting Started Packet and explore our DNA Nutrigenomic Test with Methylation Pathway Analysis.

 

 

Related FAQs

What does the Methylation Pathway Analysis do for me? 

Dr. Amy likes to think of the Methylation Pathway Analysis as a road map. If you want to take a road trip from your hometown to a vacation destination of your choice (symbolic of your health goal!), you need a map with detailed directions. You’ll want to know the best route to take to avoid damaged roads, closures, construction, and traffic. Your Methylation Pathway Analysis tells you where all of these detours are located, so you can find the best way to get to where you want to go. The more information you have about genetic mutations in your pathway, the easier it is to create your road map and eliminate the guesswork on your journey to optimal health and wellness. Genetic mutations within the methylation cycle are well defined, so you are able to utilize the data to provide a clear path to what supports are needed to help bypass mutations that are present. By understanding your nutritional needs and genetics, you can better manage your overall health and maintain proper function of the methylation cycle.

How often should I run an at-home test kit? 

Determining how often you should run an at-home test kit, and which test kit to choose, depends on the individual and their health goals. The skim, swim, and dive sections of Dr. Amy’s free Getting Started packet help guide where to start, and how frequently to follow up with additional testing.

If you’re thinking about taking an at-home test kit but aren’t sure where to start, explore our at-home test quiz.

How can I be sure the supplements I’m taking are helping?

Biochemical testing reflects your progress in overcoming imbalances through the use of supplementation. Running follow-up at-home tests helps to ensure that the supplements you have added are working to achieve the goals you and your health care professional have set. 



The information expressed on this webpage does not constitute an attempt to practice medicine nor does it establish a doctor-patient relationship. Content on the site is for informational and educational purposes only. The information expressed is not meant to replace you working with a physician or health care practitioner.

Information and statements have not been evaluated by the U.S. Food & Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent any disease or be used as the basis for treating a particular symptom or disease. Any products discussed or endorsed are not intended to diagnose, treat, cure or prevent any diseases or be used as the basis for treating a particular symptom or disease. If you have specific healthcare concerns or questions about the products displayed, contact your licensed healthcare professional for advice or answers.

 



 

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