The SUOX gene gives your body instructions on how to make the enzyme sulfite oxidase. This enzyme helps break down amino acids containing sulfur that your body no longer needs. It does this by facilitating the conversion of sulfite to sulfate.1,2
The critical role of the SUOX enzyme is to detoxify sulfites in the body. Sulfites are generated as a natural byproduct of the methylation cycle and can also be ingested from the food that we eat. Exposure to sulfites can induce a range of adverse effects in sensitive individuals, including dermatitis, hives, flushing, abdominal pain and diarrhea, and anaphylactic and asthmatic reactions.3
Mutations in SUOX may be a risk factor for isolated sulfite oxidase deficiency and polycystic ovarian syndrome.2,4
The SUOX SNP that Dr. Amy focuses on is a mutation that results in decreased SUOX activity.
I’m not sure if I have a SUOX mutation, how can I find out?
Our DNA Nutrigenomic Test identifies a custom panel of 30 single nucleotide polymorphisms (SNPs), designed by Dr. Amy. This panel tests for the SUOX S370S variation.
While there are thousands of genes and SNPs that can be examined, Dr. Amy has designed The DNA Nutrigenomic Test panel to focus on 30 SNPs that are part of the methylation cycle. This is a key nutritional pathway in the body that is central to health.
Many of the SNPs in Dr. Amy’s custom panel are in the control or regulatory portion of the gene, meaning these SNPs can have a significant impact on your health. These include some of the more unique SNPs on this panel and are not always covered by other DNA profile tests.
The analysis includes supplement suggestions based on personalized results and provides a comprehensive assessment of the methylation cycle. Proper function of the methylation cycle is essential for several key pathways in the body. When genetic mutations, or “weaknesses”, are present in this cycle, there may be increased risk factors for a range of health concerns. To learn more about the DNA Nutrigenomic Test and The Yasko Protocol, read our Getting Started Packet here.
How can I support my SUOX mutation?
Nutrigenomic pathways are different between individuals and proper supplementation can help support specific imbalances. Holistic Health International offers a variety of supplements to support a SUOX mutation within the SNP Support Category here.
Sulfite Sensitive™ capsules were originally named after those with MTR/MTRR/SUOX mutations in their genetics. These capsules help support low levels of manganese and/or molybdenum, as well as individuals with high levels of taurine and/or sulfur. May be helpful for individuals struggling with chronic fatigue, issues with yeast, sensitive skin, and allergy intolerances related to sulfites.
You do not need to use every supplement listed in each category! Supplements are provided as options to discuss with your own health care professional, to gradually add in as you feel they are needed, and for additional consideration based on biochemical test results.
The beauty of looking at targeted SNPs in the methylation cycle is that it’s a nutritional pathway, meaning if you find a mutation or imbalance in your system, you have ways to support or bypass them.
The information expressed on this webpage does not constitute an attempt to practice medicine nor does it establish a doctor-patient relationship. Content on the site is for informational and educational purposes only. The information expressed is not meant to replace you working with a physician or health care practitioner.
Information and statements have not been evaluated by the U.S. Food & Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent any disease or be used as the basis for treating a particular symptom or disease. Any products discussed or endorsed are not intended to diagnose, treat, cure or prevent any diseases or be used as the basis for treating a particular symptom or disease. If you have specific healthcare concerns or questions about the products displayed, contact your licensed healthcare professional for advice or answers.
References:
1. P51687 · SUOX_HUMAN. Accessed 2023, April 25. https:// www.uniprot.org/uniprotkb/P51687/entry
2. SUOX sulfite oxidase [ Homo sapiens (human) ]. 2023, March 29. Accessed 2023, April 25. https://www.ncbi.nlm.nih.gov/ gene/6821
3. Vally H, Misso NL. Adverse reactions to the sulphite additives. Gastroenterol Hepatol Bed Bench. Winter 2012;5(1):16-23.
4. SUOX gene sulfite oxidase. 2018, January 1. Accessed 2023, April 25. https://medlineplus.gov/genetics/gene/ suox/#synonyms
